Lola Kirke as Greta, a young woman Amy meets at the Ozarks campground.Casey Wilson as Noelle Hawthorne, Nick and Amy's neighbor.Emily Ratajkowski as Andie Fitzgerald, Nick's mistress and student.Missi Pyle as Ellen Abbott, a cable TV host based on Nancy Grace.Patrick Fugit as Officer James Gilpin, Boney's partner.Kim Dickens as Detective Rhonda Boney, the lead investigator on Amy's disappearance.Carrie Coon as Margo 'Go' Dunne, Nick's twin sister.Tyler Perry as Tanner Bolt, Nick's attorney.Neil Patrick Harris as Desi Collings, Amy's wealthy ex-boyfriend.Rosamund Pike as Amy Elliott Dunne, Nick's missing wife.The 'happy' couple announces on television that they are expecting a child. Despite Margo's objections, Nick reluctantly decides to stay with Amy.
He then reacts violently to Amy's insistence that they remain married, but feels responsible for the child. Nick doubts the child is his and says he will take a paternity test. Nick intends to leave Amy and expose her lies, but Amy reveals she is pregnant, having artificially inseminated herself with Nick's sperm stored at a fertility clinic.
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